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Crenulin-RCC ^® : Blood and Tissue Oxygenation

~Dr. Daniel B. Mowrey, Ph.D.

This paper describes the research reported by a team of Chinese scientists on a native combination of plant materials which demonstrated an ability to improve the oxygenation of blood and body cells. The highlands of China and Tibet is the habitat of the main component of this herbal mixture and historical accounts of the invasion of Tibet inform us that the success of those military campaigns was attributed largely to the ability of this plant to aid the soldiers in adapting to the leaner oxygen content of air in the much higher elevations of Tibet. Scientists who were aware of these records as well as the widespread folklore use of the formula for similar purposes decided to investigate these properties under more controlled circumstances. The results of their experiments as reported by the researchers are repeated here.

For the purposes of this paper the Chinese formula will be referred to as Crenulin-RCC, the proprietary name by which it is known in marketplace. It contains a proprietary combination of three herbs: Sedum Crenulata, Hippophae Rhamnoides, and Fructus Lychii.

The Primary Findings in Human Subjects

1. The studies showed that Crenulin-RCC enhanced the oxygenation of the blood.

a. In healthy people it significantly increased the amount of oxygen in the (arterial) blood, as measured by a rise in PaO, or partial pressure of blood oxygen, and by rises in SaO, or saturation of blood oxygen.

b. In healthy people Crenulin-RCC significantly improved tissue oxygenation, as measured by reductions in blood viscosity. In other words, it affected the blood in such a manner as to increase the blood's ability to release oxygen into the body's tissues.

2. The studies showed that Crenulin-RCC increased exercise performance under hypoxic conditions.

a. In healthy people, Crenulin-RCC significantly reduces the effect of altitude (which lowers available oxygen) on work performance (as measured by a cycle ergometer, a kind of treadmill). The thought is that Crenulin-RCC helps offset the effects of reduced oxygen supply at altitude because it improves the body's ability to extract what little oxygen there is in the air and deliver it to the tissues.

b. In healthy people, Crenulin-RCC significantly altered the anaerobic threshold (AT) compared to controls. The AT is a measure of how long a person can exercise before their oxygen supply is reduced to such an extent that anaerobic metabolism takes over. At altitude, the AT is significantly lowered (by about 30%); that means that a person enters anaerobic metabolism much more quickly than he or she would at sea level. In persons consuming Crenulin-RCC^® the AT is only reduced by less than half that amount (14.4%). That suggests that exercising people using Crenulin-RCC should maintain adequate oxygen levels longer than people not using the compound.

The Secondary Findings in Human Subjects

The consumption of Crenulin-RCC resulted in the following observed and/or reported effects:

Improvement in appetite, sleeping, vigor, and stamina.
No abnormal changes in measures of liver and kidney health.
Improvement in free radical inhibition.
Improvement in memory and learning.
Improvement in the symptoms of altitude erythrocytosis.
Increases in testosterone.

The Results of Animal Studies

In animal experiments carried out by the Chinese team the Crenulin-RCC combination was reported to produce the following effects:

1. Increased survival time of swimming mice during hypoxia.

Lowered blood lactate (measure of fatigue) of swimming rats during hypoxia.
Improved blood ATP content (measure of energy) of swimming rats during hypoxia.
Increased oxidative phosphorylation (measure of work output) of swimming rats during hypoxia.
Increased serum testosterone (measure of virility) of swimming rats during hypoxia.

Conclusion

These investigations into the properties of Crenulin-RCC appear to confirm much of the folklore use of the plant by natives of the high altitude regions of China and Tibet. The findings also lend credence to the historical records surround the eventual successful invasion of Tibet by the Chinese lowlanders (who had been repeatedly rebuffed by the Tibetans on earlier attempts to overrun the country). This powerful tool is now available for all people to use in their efforts to achieve improved performance, whether that might involve athletic gains or helping to overcome reduced oxygen capacity. Smokers, weekend warriors, joggers, sprinters, weightlifters, or people simply facing the occasional physical demands of daily (or nightly) tasks requiring additional endurance or performance, will all want the advantages Crenulin-RCC^® has to offer.

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